Aprotinin a new drug candidate for the treatment of COVID-19

Aprotinin a new drug candidate for the treatment of COVID-19

Researchers from the University of Kent, the Goethe-University in Frankfurt am Main (Germany), and the Hannover Medical School (Germany) have identified a drug with the potential to provide a treatment for COVID-19.

The international team led by Professor Martin Michaelis, Dr Mark Wass (both School of Biosciences, University of Kent), and Professor Jindrich Cinatl (Institute of Medical Virology, Goethe-University) found that the approved protease inhibitor aprotinin displayed activity against SARS-CoV-2, the coronavirus that causes COVID-19, in concentrations that are achieved in patients. Aprotinin inhibits the entry of SARS-CoV-2 into host cells and may compensate for the loss of host cell protease inhibitors that are downregulated upon SARS-CoV-2 infection.

Aprotinin aerosols are approved in Russia for the treatment of influenza and could be readily tested for the treatment of COVID-19.

Professor Martin Michaelis said: ‘”he aprotinin aerosol has been reported to be tolerated extremely well in influenza patients. Hence, it may have a particular potential to prevent severe COVID-19 disease when applied early after diagnosis.”



from ScienceBlog.com https://ift.tt/2TEgQXp

Comments

Post a Comment

Popular posts from this blog

‘Massive-scale mobilization’ necessary for addressing climate change, scientists say

Image
A year after a global coalition of more than 11,000 scientists declared a climate emergency, Oregon State University researchers who initiated the declaration released an update today that points to a handful of hopeful signs, but shares continued alarm regarding an overall lack of progress in addressing climate risks. “Young people in more than 3,500 locations around the world have organized to push for urgent action,” said Oregon State University’s William Ripple, who co-authored “The Climate Emergency: 2020 in Review,” published today in Scientific American. “And the Black Lives Matter movement has elevated social injustice and equality to the top of our consciousness. “Rapid progress in each of the climate action steps we outline is possible if framed from the outset in the context of climate justice – climate change is a deeply moral issue. We desperately need those who face the most severe climate risks to help shape the response.” One year ago, Ripple, distinguished profess...
Read more

Wiggling worms suggest link between vitamin B12 and Alzheimer’s

Image
Worms don’t wiggle when they have Alzheimer’s disease. Yet something helped worms with the disease hold onto their wiggle in Professor Jessica Tanis’s lab at the University of Delaware. In solving the mystery, Tanis and her team have yielded new clues into the potential impact of diet on Alzheimer’s, the dreaded degenerative brain disease afflicting more than 6 million Americans. A few years ago, Tanis and her team began investigating factors affecting the onset and progression of Alzheimer’s disease. They were doing genetic research with  C. elegans , a tiny soil-dwelling worm that is the subject of numerous studies. Expression of amyloid beta, a toxic protein implicated in Alzheimer’s disease, paralyzes worms within 36 hours after they reach adulthood. While the worms in one petri dish in Tanis’s lab were rendered completely immobile, the worms of the same age in the adjacent petri dish still had their wiggle, documented as “body bends,” by the scientists. “It was an observa...
Read more

Addressing Concerns About ScienceFather Awards: Our Commitment to Transparency and Integrity

Image
At ScienceFather , we pride ourselves on maintaining the highest standards of transparency, credibility, and integrity in all our activities. Our awards, including the Best Researcher Award, are built on a rigorous selection process that evaluates the quality of research, innovation, and contributions across a wide range of fields. We understand that there may be concerns or misinformation circulating online about our organization. We take these concerns seriously and are actively working to clarify any misunderstandings. It is essential to address the misconceptions and provide an accurate picture of what ScienceFather stands for. Award Legitimacy: A Globally Recognized Honor The Best Researcher Award is a distinguished honor recognized around the world, with recipients from over 112 countries . Our selection process is based solely on the quality of research. There are no costs associated with the review or selection process , ensuring that the recognition is purely merit-based. Fi...
Read more